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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human TAB2 expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1/200 - 1/400|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15713 targets TAB2 in FACS and WB applications and shows reactivity with Human samples.
The MA5-15713 immunogen is purified recombinant fragment of human TAB2 expressed in E. Coli.
MA5-15713 detects TAB2 which has a predicted molecular weight of approximately 80kDa.
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB , which may regulate the development and function of osteoclasts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CHTD2; FLJ21885; KIAA0733; MAP3K7IP2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAB2; TAK1-binding protein 2
CHTD2; KIAA0733; MAP3K7IP2; TAB-2; TAB2