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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids 951-1000 of human TAF II p135|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:200|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody detects endogenous protein at a molecular weight of 135 kDa and 105 kDa.
Purity is >95% by SDS-PAGE.
TAF II p105, also called TAF4B, is a celltype specific transcriptional co-activator that is a component of the TFIID complex. Expressed primarily in B cells and ovarian granulosa cells, TAF II p105 can interact with OCBA/POU2AF1 to activate B cell-specific octamerdependent transcription. Additionally, TAF II p105 plays an important role in co-activating the transcription factor NFkB and is essential for activation of anti-apoptotic genes such as TNFAIP3. TAF II p135, also known as TAF4, TAF2C, TAF2C1, TAF4A or TAFII130, is a 1,085 amino acid subunit of TFIID that accelerates transcriptional activation triggered by thyroid hormone (TR) or retinoic acid (RA). Localized to the nucleus, TAF II p135 contains one TAFH domain and is thought to bind to proteins that contain glutamine-rich domains, such as the transcription factor CREB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
RNA polymerase II TBP-associated factor subunit C; TAF(II)105; TAF(II)130; TAF(II)135; TAF2C; TAF2C1; TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa; TAF4A; TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD; TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa; TAFII 130; TAFII 135; TAFII-130; TAFII-135; TAFII130; TAFII135; TATA box binding protein (TBP)-associated factor 4B; TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD; TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD; TATA box binding protein associated factor 4; TATA box binding protein associated factor 4b; TBP associated factor 4; TBP Associated transcription Factor family member; TBP-associated factor 4; Transcription initiation factor TFIID 105 kDa subunit; Transcription initiation factor TFIID 130 kDa subunit; transcription initiation factor TFIID 135 kD subunit; Transcription initiation factor TFIID 135 kDa subunit; Transcription initiation factor TFIID subunit 4; Transcription initiation factor TFIID subunit 4B
SPGF13; TAF2C; TAF2C1; TAF2C2; TAF4; TAF4A; TAF4B; TAFII105; TAFII130; TAFII135