|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Membrane-enriched fraction of a human breast carcinoma liver metastasis|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-12065 targets TAG-72/CA 72-4 in FACS and immunohistochemistry (paraffin) applications and shows reactivity with human samples.
The MA5-12065 immunogen is membrane-enriched fraction of a human breast carcinoma liver metastasis.
Tumor-associated glycoprotein (TAG-72) is an oncofetal antigen with properties of a mucin. About 60% of carcinoma patients express TAG-72 in their sera.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Expression of underglycosylated MUC1 antigen in cancerous and adjacent normal breast tissues.
MA5-12065 was used in immunohistochemistry to study the potential diagnostic value of underglycosylated MUC1 antigen in breast cancer
|Ghosh SK,Pantazopoulos P,Medarova Z,Moore A||Clinical breast cancer (13:109)||2013|
TMTP1, a novel tumor-homing peptide specifically targeting metastasis.
MA5-12065 was used in immunohistochemistry to investigate the involvement of tumor-homing peptide TMTP1 in tumor metastasis
|Yang W,Luo D,Wang S,Wang R,Chen R,Liu Y,Zhu T,Ma X,Liu R,Xu G,Meng L,Lu Y,Zhou J,Ma D||Clinical cancer research : an official journal of the American Association for Cancer Research (14:5494)||2008|
Biphasic malignant mesothelioma cases with osseous differentiation and long survival: a review of the literature.
MA5-12065 was used in immunohistochemistry to report two clinical cases of biphasic malignant mesothelioma with osseous differentiation
|Demirag F,Unsal E,Tastepe I||Lung cancer (Amsterdam, Netherlands) (57:233)||2007|
The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-ß secretion from monocytes/macrophages through the DAP12-Syk pathway.
MA5-12065 was used in western blot to study the role of the DAP12-Syk pathway in the mechanism by which interaction of Siglec-15 with tumor-associated sialy-Tn antigen promotes monocyte/macrophage TGF-beta secretion
|Takamiya R,Ohtsubo K,Takamatsu S,Taniguchi N,Angata T||Glycobiology (23:178)||2013|