|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Transporter Associated with Antigen Processing (TAP-I ) peptide corresponding to the C-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).|
|Storage buffer||0.02M potassium phosphate, pH 7.2, with 0.15M NaCl|
|Contains||0.01% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:10,000|
|Western Blot (WB)||1:1000|
PA1-31487 detects TAP I from human samples.
PA1-31487 has been successfully used in flow cytometry, immunoprecipitation, Western blot applications.
The PA1-31487 immunogen is: Transporter Associated with Antigen Processing (TAP-I ) peptide corresponding to the C-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
ABC transporter, MHC 1; ABC17; ABCB2; ATP-binding cassette sub-family B member 2; ATP-binding cassette, sub-family B (MDR/TAP), member 2; D6S114E; DAAP-57C1.5; FLJ26666; FLJ41500; peptide supply factor 1; peptide transporter involved in antigen processing 1; peptide transporter PSF1; peptide transporter TAP1; PSF1; really interesting new gene 4 protein; RING4; TAP1*0102N; TAP1N; transporter 1 ATP-binding cassette sub-family B; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); transporter associated with antigen processing; transporter, ATP-binding cassette, major histocompatibility complex, 1
ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1; RING4; TAP1; TAP1*0102N; TAP1N; Y3