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Immunogen Sequence: LYQMQFTQAV EVLLSIYPRV QKAVGSSEKI FEYLDRTPRC PPSGLLTPLH LEGLVQFQDV SFAYPNRPDV LVLQGLTFTL RPGEVTALVG PNGSGKSTVA ALLQNLYQPT GGQLLLDGKP LPQYEHRYLH RQVAAVGQEP QVFGRSLQEN IAYGLTQKPT MEEITAAAVK SGAHSFISGL PQGYDTEVDE AGSQLSGGQR QAVALARALI RKPCVLILDD ATSALDANSQ LQVEQLLYES PERYSRSVLL ITQHLSLVEQ ADHILFLEGG AIREGGTHQQ LMEKKGCYWA MVQAPADAPE
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
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Protein Aliases: ABC transporter, MHC 1; ABC transporter, MHC, 1; Antigen peptide transporter 1; AOI; APT1; ATP dependent transport protein family member; ATP-binding cassette sub-family B member 2; ATP-binding cassette transporter, major histocompatibility complex, 1; ATP-binding cassette, sub-family B (MDR/TAP), member 2; beta-filamin; DAAP-57C1.5; FH1; filamin homolog 1; filamin-3; filamin-B; FLJ26666; FLJ41500; FLN1L; Histocompatibility antigen modifier 1; LRS1; Peptide supply factor 1; Peptide transporter involved in antigen processing 1; Peptide transporter PSF1; Peptide transporter TAP1; PSF-1; Really interesting new gene 4 protein; RING4; TABP; tap i; thyroid autoantigen; transporter 1 ABC (ATP binding cassette); transporter 1 ATP-binding cassette sub-family B; transporter 1, ABC (ATP binding cassette); transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); transporter associated with antigen processing; transporter associated with antigen processing 1; transporter, ABC, MHC, 1; transporter, ATP-binding cassette, major histocompatibility complex, 1
Gene Aliases: ABC17; ABCB2; APT1; Cim; D6S114E; Ham-1; Ham1; MTP1; PSF-1; PSF1; RING4; TAP; Tap-1; TAP1; TAP1*0102N; TAP1N; Tap2; Y3
UniProt ID: (Human) Q03518, (Mouse) P21958
Entrez Gene ID: (Human) 6890, (Mouse) 21354, (Rat) 24811
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