|Tested species reactivity||Human, Mouse, Non-human primate, Rat|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues near the carboxy-terminus of TBK1/NAK|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
It is not recommended to aliquot this antibody.
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.
PA5-17478 was used in western blot to identify gene variants that contribute to amyotrophic lateral sclerosis
|Freischmidt A,Wieland T,Richter B,Ruf W,Schaeffer V,Müller K,Marroquin N,Nordin F,Hübers A,Weydt P,Pinto S,Press R,Millecamps S,Molko N,Bernard E,Desnuelle C,Soriani MH,Dorst J,Graf E,Nordström U,Feiler MS,Putz S,Boeckers TM,Meyer T,Winkler AS,Winkelman J,de Carvalho M,Thal DR,Otto M,Brännström T,Volk AE,Kursula P,Danzer KM,Lichtner P,Dikic I,Meitinger T,Ludolph AC,Strom TM,Andersen PM,Weishaupt JH||Nature neuroscience (18:631)||2015|