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Product Details
MUB2005P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4D6
Immunogen
TBX-2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
JA4 recognizes a linear epitope in domains 1 and 2 of ICAM-3.
The antibody may be stored at 4 C. For prolonged storage prepare appropriate aliquots and store at or below -20 C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4 C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.
Target Information
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ10169; T-box protein 2; T-box transcription factor TBX2
Gene Aliases: TBX2
UniProt ID: (Human) Q13207
Entrez Gene ID: (Human) 6909
negative regulation of transcription from RNA polymerase II promoter
heart looping
outflow tract septum morphogenesis
outflow tract morphogenesis
endocardial cushion morphogenesis
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
transcription, DNA-templated
Notch signaling pathway
muscle cell fate determination
cell aging
regulation of heart contraction
positive regulation of cell proliferation
embryonic heart tube development
aorta morphogenesis
atrioventricular canal development
embryonic digit morphogenesis
negative regulation of transcription, DNA-templated
embryonic camera-type eye morphogenesis
cardiac muscle tissue development
palate development
positive regulation of cardiac muscle cell proliferation
pharynx development
developmental growth involved in morphogenesis
mammary placode formation
cellular senescence
negative regulation of heart looping
negative regulation of cardiac chamber formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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