|Gel Shift (GS)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||His-tagged fusion protein to residues 31-331 of the human TCF.|
|Storage buffer||0.1M tris glycine, pH 7.4, with 30% glycerol, 0.15M NaCl|
|Contains||0.08% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
TCF 4 (T cell factor 4) is a member of the TCF/LEF (lymphoid enhancer factor) family of transcription factors. Members of this family along with b catenin, are involved in mediating Wnt signaling by transactivating downstream genes. TCF 4 generates transcriptionally active complexes with b catenin in colon carcinoma cells. Expression of TCF 4 is highest in the CNS and intestinal epithelium where Wnt signaling also plays an essential role in development. Aberrant TCF 4 transcription activity has been implicated in carcinogenesis of intestinal and mammary epithlia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BHLHB19; BHLHB21; Class A helix-loop-helix transcription factor ME2; Class B basic helix-loop-helix protein 19; Class B basic helix-loop-helix protein 21; E2A; helix-loop-helix protein HE47; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Immunoglobulin transcription factor 2; immunoglobulin transcription factor-2; ITF-1; ITF-2; ITF1; ITF2; Kappa-E2-binding factor; MITF-2; negative vitamin D response element-binding protein; NOL1-TCF3 fusion; SEF-2; SEF2; SL3-3 enhancer factor 2; TCF-3; TCF-4; TCF3; TCF4; Transcription factor 3; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); transcription factor 3 variant 3; Transcription factor 4; Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2); transcription factor 4, isoform C; transcription factor 4, isoform D; transcription factor 4, isoform E; transcription factor 4, isoform L; transcription factor 4, isoform M; transcription factor 4, isoform R; Transcription factor A1; Transcription factor E2-alpha; transcription factor E2a; Transcription factor ITF-1; VDR interacting repressor; vitamin D receptor-interacting repressor
Gene Aliases: 5730422P05Rik; A1; AA408400; AGM8; ALF2; ASP-I2; AW209082; BHLHB19; BHLHB21; E12; E12/E47; E2-2; E2.2; E2A; E47; FECD3; ITF-2; ITF-2b; ITF1; ITF2; ME2; MITF-2A; MITF-2B; Pan1; Pan2; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-3; TCF-4; TCF3; TCF4; Tcfe2a; TFE; VDIR
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