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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Armenian hamster / IgG|
|Immunogen||Affinity purified D0 -11.10 TCR.|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1 ug/1 million cells|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunocytochemistry (ICC)||See 1 publications below|
MA1-70045 detects alpha/beta TCR in mouse samples.
MA1-70045 has been successfully used in flow cytometry, immunoprecipitation, immunohistochemistry (frozen sections), and Western blot procedures.
The MA1-70045 immunogen is affinity purified D0 -11.10 TCR.
Stable at 4°C. For long term storage, aliquot and freeze unused portions at -20°C in volumes appropriate for single usage. Avoid repeated freeze/thaw cycles.
The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer non-covalently associated with five invariant chains including the CD3 gamma/delta/eta and zeta subunits, all of which are required for efficient surface expression. T cell activation through the TCR induces cellular differentiation and/or proliferation and the production of lymphokines and cytokines. Both the CD3 and TCR zeta subunits are proposed to be responsible for the intracellular signal transduction events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The bullseye synapse formed between CD4+ T-cell and staphylococcal enterotoxin B-pulsed dendritic cell is a suppressive synapse in T-cell response.
MA1-70045 was used in immunocytochemistry to examine the role of the immunological synapse in T cell activation.
|Lin W,Fan Z,Suo Y,Deng Y,Zhang M,Wang J,Wei X,Chu Y||Immunology and cell biology (93:99)||2015|