Product References
Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice.
Frontiers in aging neuroscience
Alfieri JA,Silva PR,Igaz LM
Thu Oct 01 00:00:00 EDT 2020
Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism.
eLife
Conlon EG,Fagegaltier D,Agius P,Davis-Porada J,Gregory J,Hubbard I,Kang K,Kim D,Phatnani H,Shneider NA,Manley JL
Fri Jul 13 00:00:00 EDT 2018
Frontotemporal dementia with trans-activation response DNA-binding protein 43 presenting with catatonic syndrome.
Neuropathology : official journal of the Japanese Society of Neuropathology
Watanabe R,Kawakami I,Onaya M,Higashi S,Arai N,Akiyama H,Hasegawa M,Arai T
Fri Jun 01 00:00:00 EDT 2018
RNA and Protein Interactors with TDP-43 in Human Spinal-Cord Lysates in Amyotrophic Lateral Sclerosis.
Journal of proteome research
Volkening K,Keller BA,Leystra-Lantz C,Strong MJ
Fri Apr 06 00:00:00 EDT 2018
Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteins.
Scientific reports
Foglieni C,Papin S,Salvadè A,Afroz T,Pinton S,Pedrioli G,Ulrich G,Polymenidou M,Paganetti P
Wed Oct 25 00:00:00 EDT 2017
Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies.
Cerebral cortex (New York, N.Y. : 1991)
Handley EE,Pitman KA,Dawkins E,Young KM,Clark RM,Jiang TC,Turner BJ,Dickson TC,Blizzard CA
Sat Jul 01 00:00:00 EDT 2017
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
Human molecular genetics
Tanaka Y,Suzuki G,Matsuwaki T,Hosokawa M,Serrano G,Beach TG,Yamanouchi K,Hasegawa M,Nishihara M
Wed Mar 01 00:00:00 EST 2017
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
Human molecular genetics
Tanaka Y,Suzuki G,Matsuwaki T,Hosokawa M,Serrano G,Beach TG,Yamanouchi K,Hasegawa M,Nishihara M
Wed Mar 01 00:00:00 EST 2017
ALS/FTLD: experimental models and reality.
Acta neuropathologica
Tan RH,Ke YD,Ittner LM,Halliday GM
Wed Feb 01 00:00:00 EST 2017
Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.
Human molecular genetics
Tanaka Y,Nonaka T,Suzuki G,Kametani F,Hasegawa M
Fri Apr 01 00:00:00 EDT 2016
Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.
Human molecular genetics
Tanaka Y,Nonaka T,Suzuki G,Kametani F,Hasegawa M
Fri Apr 01 00:00:00 EDT 2016
Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.
Human molecular genetics
Henriques A,Croixmarie V,Priestman DA,Rosenbohm A,Dirrig-Grosch S,D'Ambra E,Huebecker M,Hussain G,Boursier-Neyret C,Echaniz-Laguna A,Ludolph AC,Platt FM,Walther B,Spedding M,Loeffler JP,Gonzalez De Aguilar JL
Sun Dec 20 00:00:00 EST 2015
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
Molecular and cellular biology
Bakkar N,Kousari A,Kovalik T,Li Y,Bowser R
Wed Jul 01 00:00:00 EDT 2015
TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies.
Acta neuropathologica communications
Goossens J,Vanmechelen E,Trojanowski JQ,Lee VM,Van Broeckhoven C,van der Zee J,Engelborghs S
Wed Apr 01 00:00:00 EDT 2015
Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis.
Human molecular genetics
Osaka M,Ito D,Yagi T,Nihei Y,Suzuki N
Sun Mar 15 00:00:00 EDT 2015
TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca²⁺ signaling in motor neurons.
Neurobiology of disease
Mutihac R,Alegre-Abarrategui J,Gordon D,Farrimond L,Yamasaki-Mann M,Talbot K,Wade-Martins R
Sun Mar 01 00:00:00 EST 2015
Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation.
Annals of clinical and translational neurology
Homma S,Beermann ML,Boyce FM,Miller JB
Sun Feb 01 00:00:00 EST 2015
An acetylation switch controls TDP-43 function and aggregation propensity.
Nature communications
Cohen TJ,Hwang AW,Restrepo CR,Yuan CX,Trojanowski JQ,Lee VM
Mon Jan 05 00:00:00 EST 2015
An acetylation switch controls TDP-43 function and aggregation propensity.
Nature communications
Cohen TJ,Hwang AW,Restrepo CR,Yuan CX,Trojanowski JQ,Lee VM
Mon Jan 05 00:00:00 EST 2015
Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Alfieri JA,Pino NS,Igaz LM
Wed Nov 12 00:00:00 EST 2014
Distinct pathways leading to TDP-43-induced cellular dysfunctions.
Human molecular genetics
Yamashita M,Nonaka T,Hirai S,Miwa A,Okado H,Arai T,Hosokawa M,Akiyama H,Hasegawa M
Fri Aug 15 00:00:00 EDT 2014
Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.
Molecular neurodegeneration
Herdewyn S,Cirillo C,Van Den Bosch L,Robberecht W,Vanden Berghe P,Van Damme P
Tue Jun 17 00:00:00 EDT 2014
Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation.
Journal of neurology, neurosurgery, and psychiatry
Suárez-Calvet M,Dols-Icardo O,Lladó A,Sánchez-Valle R,Hernández I,Amer G,Antón-Aguirre S,Alcolea D,Fortea J,Ferrer I,van der Zee J,Dillen L,Van Broeckhoven C,Molinuevo JL,Blesa R,Clarimón J,Lleó A
Sun Jun 01 00:00:00 EDT 2014
TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.
PloS one
Stallings NR,Puttaparthi K,Dowling KJ,Luther CM,Burns DK,Davis K,Elliott JL
Wed May 14 00:00:00 EDT 2014
TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.
PloS one
Stallings NR,Puttaparthi K,Dowling KJ,Luther CM,Burns DK,Davis K,Elliott JL
Wed May 14 00:00:00 EDT 2014
Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.
The International journal of neuroscience
Hosokawa M,Arai T,Yamashita M,Tsuji H,Nonaka T,Masuda-Suzukake M,Tamaoka A,Hasegawa M,Akiyama H
Thu May 01 00:00:00 EDT 2014
An autopsy case of sporadic amyotrophic lateral sclerosis associated with the I113T SOD1 mutation.
Neuropathology : official journal of the Japanese Society of Neuropathology
Nakamura S,Wate R,Kaneko S,Ito H,Oki M,Tsuge A,Nagashima M,Asayama S,Fujita K,Nakamura M,Maruyama H,Kawakami H,Kusaka H
Sat Feb 01 00:00:00 EST 2014
A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation.
Neuroscience research
Akamatsu M,Takuma H,Yamashita T,Okada T,Keino-Masu K,Ishii K,Kwak S,Masu M,Tamaoka A
Sun Dec 01 00:00:00 EST 2013
The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.
Human molecular genetics
Zhang YJ,Caulfield T,Xu YF,Gendron TF,Hubbard J,Stetler C,Sasaguri H,Whitelaw EC,Cai S,Lee WC,Petrucelli L
Thu Aug 01 00:00:00 EDT 2013
Prion-like properties of pathological TDP-43 aggregates from diseased brains.
Cell reports
Nonaka T,Masuda-Suzukake M,Arai T,Hasegawa Y,Akatsu H,Obi T,Yoshida M,Murayama S,Mann DM,Akiyama H,Hasegawa M
Thu Jul 11 00:00:00 EDT 2013
Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines.
Biochimica et biophysica acta
Cassel JA,Reitz AB
Sat Jun 01 00:00:00 EDT 2013
Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.
PloS one
Dammer EB,Fallini C,Gozal YM,Duong DM,Rossoll W,Xu P,Lah JJ,Levey AI,Peng J,Bassell GJ,Seyfried NT
Tue Mar 26 00:00:00 EDT 2013
Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis.
Annals of neurology
Larman HB,Salajegheh M,Nazareno R,Lam T,Sauld J,Steen H,Kong SW,Pinkus JL,Amato AA,Elledge SJ,Greenberg SA
Fri Mar 01 00:00:00 EST 2013
Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS.
Neurobiology of disease
González-Pérez P,Lu Y,Chian RJ,Sapp PC,Tanzi RE,Bertram L,McKenna-Yasek D,Gao FB,Brown RH
Sat Dec 01 00:00:00 EST 2012
Molecular analysis and biochemical classification of TDP-43 proteinopathy.
Brain : a journal of neurology
Tsuji H,Arai T,Kametani F,Nonaka T,Yamashita M,Suzukake M,Hosokawa M,Yoshida M,Hatsuta H,Takao M,Saito Y,Murayama S,Akiyama H,Hasegawa M,Mann DM,Tamaoka A
Thu Nov 01 00:00:00 EDT 2012
Inclusion body myositis coexisting with hypertrophic cardiomyopathy: an autopsy study.
Neuromuscular disorders : NMD
Inamori Y,Higuchi I,Inoue T,Sakiyama Y,Hashiguchi A,Higashi K,Shiraishi T,Okubo R,Arimura K,Mitsuyama Y,Takashima H
Wed Aug 01 00:00:00 EDT 2012
Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking.
The EMBO journal
Cohen TJ,Hwang AW,Unger T,Trojanowski JQ,Lee VM
Wed Mar 07 00:00:00 EST 2012
Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Biochemical and biophysical research communications
Tsuji H,Nonaka T,Yamashita M,Masuda-Suzukake M,Kametani F,Akiyama H,Mann DM,Tamaoka A,Hasegawa M
Fri Jan 06 00:00:00 EST 2012
Dysfunction of the ubiquitin-proteasome system in the cerebellum of aging Ts65Dn mice.
Experimental neurology
Necchi D,Lomoio S,Scherini E
Thu Dec 01 00:00:00 EST 2011
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Nature
Deng HX,Chen W,Hong ST,Boycott KM,Gorrie GH,Siddique N,Yang Y,Fecto F,Shi Y,Zhai H,Jiang H,Hirano M,Rampersaud E,Jansen GH,Donkervoort S,Bigio EH,Brooks BR,Ajroud K,Sufit RL,Haines JL,Mugnaini E,Pericak-Vance MA,Siddique T
Sun Aug 21 00:00:00 EDT 2011
AMSH is required to degrade ubiquitinated proteins in the central nervous system.
Biochemical and biophysical research communications
Suzuki S,Tamai K,Watanabe M,Kyuuma M,Ono M,Sugamura K,Tanaka N
Fri May 20 00:00:00 EDT 2011
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
The Journal of clinical investigation
Igaz LM,Kwong LK,Lee EB,Chen-Plotkin A,Swanson E,Unger T,Malunda J,Xu Y,Winton MJ,Trojanowski JQ,Lee VM
Tue Feb 01 00:00:00 EST 2011
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
The Journal of clinical investigation
Igaz LM,Kwong LK,Lee EB,Chen-Plotkin A,Swanson E,Unger T,Malunda J,Xu Y,Winton MJ,Trojanowski JQ,Lee VM
Tue Feb 01 00:00:00 EST 2011
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Annals of neurology
Deng HX,Zhai H,Bigio EH,Yan J,Fecto F,Ajroud K,Mishra M,Ajroud-Driss S,Heller S,Sufit R,Siddique N,Mugnaini E,Siddique T
Tue Jun 01 00:00:00 EDT 2010
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Annals of neurology
Deng HX,Zhai H,Bigio EH,Yan J,Fecto F,Ajroud K,Mishra M,Ajroud-Driss S,Heller S,Sufit R,Siddique N,Mugnaini E,Siddique T
Tue Jun 01 00:00:00 EDT 2010
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.
The Journal of biological chemistry
Nishimoto Y,Ito D,Yagi T,Nihei Y,Tsunoda Y,Suzuki N
Fri Jan 01 00:00:00 EST 2010
TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Archives of neurology
Steinacker P,Hendrich C,Sperfeld AD,Jesse S,von Arnim CA,Lehnert S,Pabst A,Uttner I,Tumani H,Lee VM,Trojanowski JQ,Kretzschmar HA,Ludolph A,Neumann M,Otto M
Sat Nov 01 00:00:00 EDT 2008
Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease.
Brain research
Rohn TT
Thu Sep 04 00:00:00 EDT 2008
Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease.
Brain research
Rohn TT
Thu Sep 04 00:00:00 EDT 2008
TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.
Acta neuropathologica
Lee EB,Lee VM,Trojanowski JQ,Neumann M
Sat Mar 01 00:00:00 EST 2008
TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.
Acta neuropathologica
Lee EB,Lee VM,Trojanowski JQ,Neumann M
Sat Mar 01 00:00:00 EST 2008