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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 16 amino acid peptide near the amino terminus of the human TEM2.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Immunohistochemistry (IHC)||2.5 µg/ml|
|Western Blot (WB)||1-2 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
A suggested positive control is rat colon lysate.
PA5-20439 can be used with blocking peptide PEP-0556.
Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear.
PA5-20439 was used in immunohistochemistry - frozen section to investigate the developmental processes that regulate the formation of unique inner ear cell types
|Burns JC,Kelly MC,Hoa M,Morell RJ,Kelley MW||Nature communications (6:null)||2015|
GTP-binding protein Rhes; MGC:4834, Rhes, TEM2; Ras homolog enriched in striatum; RASD family, member 2; SE6C; Tumor endothelial marker 2
4930526B11Rik; AU045414; MGC:4834; RASD2; Rhes; TEM-2; TEM2