Keep as concentrated solution.
Positive Control: NT2D1, NT2D1 nuclear extract, DDDDK-human TET1-transfected 293T, M10.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
TET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2,136 amino acid protein that localizes to the nucleus and contains one CXXC-type zinc finger. Expressed in adult ovary, thymus and skeletal muscle and also present in fetal lung, heart and brain, TET1 is thought to play a role in the development of fetal organs and may also be involvement in the pathoegenesis and metastasis of acute myeloid leukemia (AML). The gene encoding TET1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman's syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: bA119F7.1 Antibody; CXXC finger 6; CXXC zinc finger 6; CXXC-type zinc finger protein 6; CXXC6 Antibody; LCX Antibody; Leukemia-associated protein with a CXXC domain; Methylcytosine dioxygenase TET1; Ten-eleven translocation 1 gene protein; ten-eleven translocation-1; tet methylcytosine dioxygenase 1 Antibody; tet oncogene 1; TET1 splice variant VP_DE4; TET1 splice variant VP_DE456
Gene Aliases: bA119F7.1; CXXC6; KIAA1676; LCX; MLL-TET1; TET1; TET1-MLL
UniProt ID: (Human) Q7Z6B6
Entrez Gene ID: (Human) 80312