|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||TGF-beta 1 from human platelets|
|Storage buffer||PBS, pH 7.0|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:1000|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay dependent|
|Neutralization (Neu)||Assay dependent|
|Western Blot (WB)||5-20 ng/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Blocking Assay (BLOCK)||See 3 publications below|
MA1-21595 detects TGF beta in Human samples.
MA1-21595 has been successfully used in Neutralization, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin) and Western Blot procedures. By Western blot, this antibody detects detects dimeric (25 kDa) and monomeric (12.5 kDa) forms of TGF beta, under non-reducing and reducing conditions, respectively
MA1-21595 immunogen corresponds to TGF-beta 1 from human platelets.
TGF beta (Transforming Growth Factor beta) is a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Role of gastric epithelial cell-derived transforming growth factor beta in reduced CD4+ T cell proliferation and development of regulatory T cells during Helicobacter pylori infection.
MA1-21595 was used in blocking or activating experiment to investigate the role of gastric epithelial cells in CD4+ T cell response against Helicobacter pylori infection
|Beswick EJ,Pinchuk IV,Earley RB,Schmitt DA,Reyes VE||Infection and immunity (79:2737)||2011|
|Not Applicable||Not Cited||
IL-10 producing CD8+ T cells in human infection with Leishmania guyanensis.
MA1-21595 was used in blocking or activating experiment to measure TGF-beta, IL-10, and IFN-gamma production by peripheral blood mononuclear cells of unexposed naive subjects and LCL patients after stimulation with live Leishmania guyanensis
|Bourreau E,Ronet C,Couppié P,Sainte-Marie D,Tacchini-Cottier F,Launois P||Microbes and infection (9:1034)||2007|
|Not Applicable||Not Cited||
Transforming growth factor beta 1 production by CD4+ CD25+ regulatory T cells in peripheral blood mononuclear cells from healthy subjects stimulated with Leishmania guyanensis.
MA1-21595 was used in blocking or activating experiment to show that TGF-beta1 is involved in the suppressive activity of Leishmania guyanensis-stimulated CD4+ CD25+ T cells from healthy controls
|Kariminia A,Bourreau E,Pascalis H,Couppié P,Sainte-Marie D,Tacchini-Cottier F,Launois P||Infection and immunity (73:5908)||2005|