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|Tested species reactivity||Human, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 1 and 268 of Human TGF beta Receptor I|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Contains||0.025% ProClin 300|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:50-1:200|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:1000-1:10,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-27785 targets TGF beta Receptor I in IF, IHC (P), and WB applications and shows reactivity with Human and Rat samples.
The PA5-27785 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 268 of Human TGF beta Receptor I.
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
53kD; 53kDa; AAT5; activin A receptor type II-like kinase; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; activin A receptor type II-like protein kinase of 53kD; activin receptor-like kinase 5; ACVRLK4; ALK-5; ALK5; LDS1A; LDS2A; MSSE; ser; serine/threonine-protein kinase receptor R4; SKR4; tbetaR-I; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; transforming growth factor beta receptor I; transforming growth factor, beta receptor I; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); transforming growth factor-beta receptor type I
AAT5; ACVRLK4; ALK-5; ALK5; LDS1A; LDS2A; MSSE; RP11-96L7.1; SKR4; tbetaR-I; TGFR-1
Protein metabolism and modification Protein modification Protein phosphorylation Signal transduction Cell surface receptor mediated signal transduction Cytokine and chemokine mediated signaling pathway Receptor protein serine/threonine kinase signaling pathway Developmental processes Mesoderm development