PA5-16272 targets Transglutaminase II in IHC (P), IP, and WB applications and shows reactivity with Human, mouse, and Rat samples.
The PA5-16272 immunogen is recombinant full length human TGase II.
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; G alpha h; G-ALPHA-h; GNAH; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; RP5-1054A22.2; TG C; TG(C); TGase C; TGase H; TGase-2; TGase-H; TGC; Tissue transglutaminase; tissue-type transglutaminase; transglutaminase 2, C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase-2
Gene Aliases: G[a]h; TG(C); TG2; TGase2; TgaseII; TGC; TGM2; tTG; tTGas