MA3-063 detects trans-Golgi network (TGN) 38 from human and monkey samples and both recombinant and endogenous rat samples.
MA3-063 has been successfully used in Western blot, immunofluorescence, immunocytochemistry and FACS procedures. By Western blot, this antibody detects an ~38 kDa protein representing deglycosylated recombinant rat TGN38. Under normal Western blot conditions, this antibody detects an 85-95 kDa band depending on cell type. Immunofluorescence staining of TGN38 in NRK cells with MA3-063 results in staining predominantly in the TGN.
In immunofluorescence, it has been shown that methanol works best as a fixative.
The MA3-063 immunogen is a synthetic peptide corresponding to residues L(18) P S A S K P N N T S S E N N P P(34) C of rat TGN38.
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1. and ASPP2. are activators of p53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hTGN48; hTGN51; TGN38 homolog; Trans-Golgi network glycoprotein 46; Trans-Golgi network glycoprotein 48; Trans-Golgi network glycoprotein 51; Trans-Golgi network integral membrane protein 2; Trans-Golgi network integral membrane protein TGN38; trans-Golgi network protein (46, 48, 51kD isoforms); trans-golgi network protein 1; Trans-Golgi network protein 2; trans-Golgi network protein TGN51
Gene Aliases: TGN38; TGN46; TGN48; TGN51; Tgoln1; TGOLN2; Ttgn1; TTGN2
Molecular Function: membrane traffic protein