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Product Details
66703-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A11C8
Immunogen
THRA fusion protein Ag27189
Conjugate
Form
Liquid
Concentration
1.3 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: PSYLDKDEQC VVCGDKATGY HYRCITCEGC KGFFRRTIQK NLHPTYSCKY DSCCVIDKIT RNQCQLCRFK KCIAVGMAMD LVLDDSKRVA KRKLIEQNRE RRRKEEMIRS LQQRPEPTPE EWDLIHIATE AHRSTNAQGS HWKQRRKFLP DDIGQSPIVS MPDGDKVDLE AFSEFTKIIT PAITRVVDFA KKLPMFSELP CEDQIILLKG CCMEIMSLRA AVRYDPESDT LTLSGEMAV
Target Information
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; c-erb-A thyroid hormone receptor; c-erbA-1; C-erbA-alpha; c-erbA-alpha2; c-erbAalpha; c-erbAalpha2; cerbA protein; cerbAalpha; E ERB-T-1; EAR-7; ERBA ALPHA; ERBA related 7; ERBA-related 7; MGC000261; MGC43240; Nuclear receptor subfamily 1 group A member 1; Oncogene ERBA; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1); thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; TR; TR alpha 1; TR alpha 1+2; TR alpha 2; triiodothyronine receptor; V-erbA-related protein 7
Gene Aliases: 6430529J03Rik; AR7; AW259572; c-ERBA-1; C-erba-alpha; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; Rvr; T3R[a]; T3Ralpha; THRA; THRA1; THRA2
UniProt ID: (Human) P10827, (Mouse) P63058, (Rat) P63059
Entrez Gene ID: (Human) 7067, (Mouse) 21833, (Rat) 81812
transcription regulatory region sequence-specific DNA binding
steroid receptor RNA activator RNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
steroid hormone receptor activity
thyroid hormone receptor activity
protein binding
transcription factor binding
zinc ion binding
TBP-class protein binding
protein domain specific binding
chromatin DNA binding
protein complex binding
protein homodimerization activity
transcription regulatory region DNA binding
intronic transcription regulatory region DNA binding
protein heterodimerization activity
thyroid hormone binding
DNA binding
single-stranded RNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
metal ion binding
protein dimerization activity
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
cartilage condensation
ossification
kidney development
liver development
regulation of thyroid hormone mediated signaling pathway
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
brain development
learning or memory
regulation of heart contraction
female courtship behavior
response to cold
hormone-mediated signaling pathway
positive regulation of myotube differentiation
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
erythrocyte differentiation
adrenal gland development
intracellular receptor signaling pathway
thyroid gland development
response to nutrient levels
regulation of myeloid cell apoptotic process
response to drug
cytoplasmic sequestering of transcription factor
steroid hormone mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
positive regulation of female receptivity
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
embryonic organ development
regulation of lipid catabolic process
Type I pneumocyte differentiation
negative regulation of DNA-templated transcription, initiation
transcription, DNA-templated
regulation of transcription, DNA-templated
organ morphogenesis
lung development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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