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Product Details
H00026230-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3C1
Immunogen
TIAM2 (NP_001010927, 527 a.a. approximately 624 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: DVHPEAEQQP GPESGEGQKG GEQPKLVRGH FCPIKRKANS TKRDRGTLLK AQIRHQSLDS QSENATIDLN SVLEREFSVQ SLTSVVSEEC FYETESHG
Target Information
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Rho guanine nucleotide exchange factor TIAM2; SIF and TIAM1-like exchange factor; T-lymphoma invasion and metastasis-inducing protein 2; TIAM-2
Gene Aliases: KIAA2016; STEF; TIAM-2; TIAM2
UniProt ID: (Human) Q8IVF5
Entrez Gene ID: (Human) 26230
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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