MA5-12204 targets TIMP-2 in IHC (P) and WB applications and shows reactivity with Bovine, Guinea Pig, Human, mouse, Rabbit, and Rat samples.
The MA5-12204 immunogen is a synthetic peptide from the N-terminal region of human TIMP-2 protein.
TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Collagenase inhibitor; CSC-21K; Metalloproteinase inhibitor 2; metalloproteinase inhibitor precursor; metalloproteinase inhibitor TIMP-2; testicular secretory protein Li 57; TIMP 2; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinase-2; Tissue inhibitor of metalloproteinases 2; tissue inhibitor of mettaloproteinase 2
Gene Aliases: CSC-21K; D11Bwg1104e; DDC8; Timp-2; TIMP2
Molecular Function: protease inhibitor