TLE1, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In later stages, TLE2 and TLE4 are upregulated, and expression of TLE1 decreases.
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Protein Aliases: E(Sp1) homolog; Enhancer of split groucho 1; Enhancer of split groucho like protein 1; Enhancer of split groucho-like protein 1; ESG1; GRG1; TLE 1; Tle1; TLE1_HUMAN; Transducin like enhancer of split 1; Transducin like enhancer of split 1 (E(sp1) homolog Drosophila); Transducin like enhancer of split 1 homolog of Drosophila E(sp1); Transducin like enhancer protein 1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transducin-like enhancer protein 1
Gene Aliases: ESG; ESG1; GRG1; TLE1
UniProt ID: (Human) Q04724
Entrez Gene ID: (Human) 7088