|Tested species reactivity||Mouse|
|Host / Isotype||Mouse / IgM|
|Immunogen||Synthetic peptide corresponding to residues L-G(791) G L R L C L P E R D F E P G K(806) of mouse TLR12.|
|Storage buffer||ascites diluted in PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
Based on sequence homology, this antibody may also detect mouse TLR11.
The Toll-like Receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drospphila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLR12 has been cloned that displays a distinct pattern of expression in macrophages and liver, kidney and bladder epithelial cells. TLR12 does not respond to known TLR ligands.