|Tested species reactivity||Mouse|
|Host / Isotype||Mouse / IgM|
|Immunogen||Synthetic peptide corresponding to residues L-G(791) G L R L C L P E R D F E P G K(806) of mouse TLR12.|
|Storage buffer||ascites diluted in PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Based on sequence homology, this antibody may also detect mouse TLR11.
The Toll-like Receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drospphila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLR12 has been cloned that displays a distinct pattern of expression in macrophages and liver, kidney and bladder epithelial cells. TLR12 does not respond to known TLR ligands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.