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|Tested species reactivity||Human, Non-human primate|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Human TLR4 expressed in Ba/F3 cell line.|
|Storage buffer||PBS with 5% sucrose, 1% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Blocking Assay (BLOCK)||See 1 publications below|
MA1-20237 detects TLR4 in human and Rhesus monkey samples.
MA1-20237 has been successfully used in FACS procedures.
The MA1-20237 immunogen is human TLR4 expressed in Ba/F3 cell line.
Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell population.
MA1-20237 was used in blocking or activating experiment to study the role of hepatitis C infection in the B-cell dysfunction in cirrhosis
|Doi H,Iyer TK,Carpenter E,Li H,Chang KM,Vonderheide RH,Kaplan DE||Hepatology (Baltimore, Md.) (55:709)||2012|
ARMD10; CD284; homolog of Drosophila toll; hToll; TLR-4; TOLL; Toll-like Receptor 4
ARMD10; CD284; TLR-4; TLR4; TOLL