|Tested species reactivity||Guinea pig, Human, Pig|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Ba/F3 cell line expressing TLR4|
|Storage buffer||PBS with 1% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||10 µl for 10^6 cells in 100 µl|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Blocking Assay (BLOCK)||See 1 publications below|
MA1-22766 detects TLR4 (FITC) in Human, Pig and Guinea Pig samples.
MA1-22766 has been successfully used in FACS procedures.
MA1-22766 immunogen corresponds to Ba/F3 cell line expressing TLR4.
Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell population.
MA1-22766 was used in blocking or activating experiment to study the role of hepatitis C infection in the B-cell dysfunction in cirrhosis
|Doi H,Iyer TK,Carpenter E,Li H,Chang KM,Vonderheide RH,Kaplan DE||Hepatology (Baltimore, Md.) (55:709)||2012|