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|Tested species reactivity||Dog, Guinea pig, Human, Non-human primate, Pig|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Ba/F3 cell line expressing TLR4 (CD284).|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:10 - 1:50|
|Functional Assay (FN)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Blocking Assay (BLOCK)||See 1 publications below|
This product is a low-endotoxin, preservative-free formulation. Endotoxin level is <0.01 EU/ug.
For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell population.
MA1-80122 was used in blocking or activating experiment to study the role of hepatitis C infection in the B-cell dysfunction in cirrhosis
|Doi H,Iyer TK,Carpenter E,Li H,Chang KM,Vonderheide RH,Kaplan DE||Hepatology (Baltimore, Md.) (55:709)||2012|
ARMD10; CD284; homolog of Drosophila toll; hToll; TLR-4; TOLL; Toll-like Receptor 4
ARMD10; CD284; TLR-4; TLR4; TOLL