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|Tested species reactivity||Human , Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||synthetic peptide ELQVLDLSRCEIQTIEDG, corresponding to amino acids 39-56 of Mouse TLR4.|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-28112 detects TLR4 from mouse, human samples.
PA1-28112 has been successfully used in Western blot applications. Western blot detects a band of ~74-80kDa (predicted molecular weight 96kDa).
The PA1-28112 immunogen is synthetic peptide: ELQVLDLSRCEIQTIEDG, corresponding to amino acids 39-56 of Mouse TLR4.
Postive Control of partial recombinant mouse TLR4 (extracellular portion plus His-tag) suggested.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
Toll-like receptors (TLR) are higher conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosphilia toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type 1 transmembrane signaling receptors with pattern recognition capabilities have been implicated in the innate host defense to pathogens.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
hToll, homolog of Drosophila toll, lipopolysaccharide response, toll-like receptor 4, Toll-like Receptor 4, ARMD10, CD284, TLR-4, TOLL
CD284, TLR-4, Ran/M1, ARMD10, Ly87, TOLL, Lps, Rasl2-8
Signal transduction Cell surface receptor mediated signal transduction Cytokine and chemokine mediated signaling pathway Immunity and defense T-cell mediated immunity Granulocyte-mediated immunity Macrophage-mediated immunity