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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2a, kappa|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The Extracellular IFI16 Protein Propagates Inflammation in Endothelial Cells Via p38 MAPK and NF-?B p65 Activation.
A18433 was used in flow cytometry to study the effect of recombinant IFI16 protein on primary endothelial cells
|Bawadekar M,De Andrea M,Lo Cigno I,Baldanzi G,Caneparo V,Graziani A,Landolfo S,Gariglio M||Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research (35:441)||2015|
CD284, ARMD10, TOLL, TLR-4
hToll, homolog of Drosophila toll, toll-like receptor 4, Toll-like Receptor 4, ARMD10, CD284, TLR-4, TOLL