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|Tested species reactivity||Porcine|
|Published species reactivity||Porcine|
|Host / Isotype||Rabbit / IgG1|
|Immunogen||Recombinant porcine TNF alpha (Baculovirus-derived)|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 3 publications below|
MP391 targets TNF Alpha in ELISA, and WB applications and shows reactivity with Porcine samples.
The MP391 immunogen is recombinant porcine TNF alpha (Baculovirus-derived).
MP391 detects TNF Alpha which has a predicted molecular weight of approximately 25 kDa.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Classical swine fever virus induces tumor necrosis factor-alpha and lymphocyte apoptosis.
MP391 was used in immunohistochemistry to study the effect of classical swine fever virus on tumor necrosis factor alpha production and lymphocyte apoptosis
|Choi C,Hwang KK,Chae C||Archives of virology (149:875)||2004|
Percutaneous plasma decompression alters cytokine expression in injured porcine intervertebral discs.
MP391 was used in immunohistochemistry to study the effect of percutaneous plasma decompression on degenerating porcine intervertebral discs
|O'Neill CW,Liu JJ,Leibenberg E,Hu SS,Deviren V,Tay BK,Chin CT,Lotz JC||The spine journal : official journal of the North American Spine Society (4:88)||2004|
Lipopolysaccharide induces inflammatory cytokines in the pig amnion.
MP391 was used in immunohistochemistry to investigate the effect of lipopolysaccharide on cytokine production in the pig amnion
|Trebichavský I,Splíchal I,Zahradnícková M,Splíchalová A,Mori Y||Veterinary immunology and immunopathology (87:11)||2002|
cachectin; TNF-a; TNF-alpha; tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2; tumor-necrosis factor
SBAB-548A10.2; TNF; TNFA; TNFSF2