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|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant human TNF alpha from Pichia pastoris.|
|Storage buffer||PBS with 5% trehalose|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
M2TNFAI targets TNF Alpha in ELISA applications and shows reactivity with Human samples.
The M2TNFAI immunogen is recombinant human TNF alpha from Pichia pastoris.
M2TNFAI detects TNF Alpha which has a predicted molecular weight of approximately 26 kDa.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Enhanced interleukin-12 and CD40 ligand activities but reduced Staphylococcus aureus Cowan 1-induced responses suggest a generalized and progressively impaired type 1 cytokine pattern for human schistosomiasis.
M2TNFAI was used in ELISA to study the role of type 1 cytokine in chronic hepatosplenic schistosomiasis
|Montenegro SM,Abath FG,Domingues AL,Melo WG,Morais CN,Coutinho EM,Mahanty S,Wynn TA||Infection and immunity (70:5903)||2002|
Human dendritic cells are activated by dengue virus infection: enhancement by gamma interferon and implications for disease pathogenesis.
M2TNFAI was used in ELISA to investigate the effect of dengue virus infection on human dendritic cells
|Libraty DH,Pichyangkul S,Ajariyakhajorn C,Endy TP,Ennis FA||Journal of virology (75:3501)||2001|
Generation and cytotoxic profile of human peripheral blood CD4+ T lymphocytes.
M2TNFAI was used in blocking/activating experiment to investigate the mechanisms of cytotoxicity employed by CD4+ T cells
|Smyth MJ||Immunology and cell biology (70 ( Pt 6):379)||1992|
APC1 protein; cachectin; TNF superfamily, member 2; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; tumor necrosis factor alpha; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
DIF; TNF; TNF-alpha; TNFA; TNFSF2; TNLG1F