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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant mouse TNF alpha|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
PMTNFABI targets TNF Alpha in ELISA, and WB applications and shows reactivity with mouse samples.
The PMTNFABI immunogen is recombinant mouse TNF alpha.
PMTNFABI detects TNF Alpha which has a predicted molecular weight of approximately 26 kDa.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Modulation of cytokine production by 7-hydroxycoumarin in vitro and its efficacy against influenza infection in mice.
PMTNFABI was used in western blot to study the effects of 7-hydroxycoumarin on in vitro cytokine production and influenza infectivity in a murine intranasal infection model
|Kurokawa M,Watanabe W,Shimizu T,Sawamura R,Shiraki K||Antiviral research (85:373)||2010|
Cytokine-regulatory activity and therapeutic efficacy of cinnamyl derivatives in endotoxin shock.
PMTNFABI was used in western blot to study the effect of cinnamyl compounds on cytokine production and recovery from endotoxin shock
|Kurokawa M,Brown J,Kagawa Y,Shiraki K||European journal of pharmacology (474:283)||2003|
cachectin; TNF alpha; TNF-a; tumor necrosis factor; tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
DIF; Tnf; TNF-a; TNF-alpha; Tnfa; TNFalpha; Tnfsf1a; TNFSF2