|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Recombinant human sTNF-r.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:150|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
IP-MS enrichment of TNFRSF1A (LFQ intensity): TNFRSF1A was enriched 463-fold from A549 lysate compared to background proteins, using the optimized IP-MS workflow with Pierce MS-Compatible Magnetic IP Kit protein A/G (Part No. 90409) and TNFRSF1A antibody (Part No. 33-0100). The STRING database (www.string-db.org) was used to identify the protein interactor list. See more information on IP-MS verification of antibody selectivity. IP-MS validation info.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Human||Not Cited||Neutrophils promote aerogenous spread of lung adenocarcinoma with bronchioloalveolar carcinoma features.||Wislez M,Antoine M,Rabbe N,Gounant V,Poulot V,Lavolé A,Fleury-Feith J,Cadranel J||Clinical cancer research : an official journal of the American Association for Cancer Research (13:3518)||2007|
|Mouse||1:100||Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures.||Penkowa M,Molinero A,Carrasco J,Hidalgo J||Neuroscience (102:805)||2001|
|A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.||Chan FK,Chun HJ,Zheng L,Siegel RM,Bui KL,Lenardo MJ||Science (New York, N.Y.) (288:2351)||2000|