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|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Recombinant human sTNF-r.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:150|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Human||Not Cited||Neutrophils promote aerogenous spread of lung adenocarcinoma with bronchioloalveolar carcinoma features.||Wislez M,Antoine M,Rabbe N,Gounant V,Poulot V,Lavolé A,Fleury-Feith J,Cadranel J||Clinical cancer research : an official journal of the American Association for Cancer Research (13:3518)||2007|
|Mouse||1:100||Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures.||Penkowa M,Molinero A,Carrasco J,Hidalgo J||Neuroscience (102:805)||2001|
|A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.||Chan FK,Chun HJ,Zheng L,Siegel RM,Bui KL,Lenardo MJ||Science (New York, N.Y.) (288:2351)||2000|
CD120a; FPF; MGC19588; p55-R; TBP1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-RI; TNFAR; TNFR-I; TNFR1; TNFR55; TNFR60; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type 1; tumor necrosis factor-alpha receptor
CD120a; FPF; MS5; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55; TNFR60; TNFRSF1A