TNF alpha (Adalimumab) Recombinant Human Monoclonal Antibody (D2E7)

transcription regulatory region sequence-specific DNA binding protease binding cytokine activity tumor necrosis factor receptor binding protein binding identical protein binding receptor agonist activity histone H3K9ac reader activity

negative regulation of transcription from RNA polymerase II promoter response to hypoxia microglial cell activation positive regulation of cytokine production negative regulation of endothelial cell proliferation response to amphetamine negative regulation of L-glutamate transport macrophage activation involved in immune response chronic inflammatory response to antigenic stimulus positive regulation of immunoglobulin production regulation of production of molecular mediator of immune response negative regulation of cytokine production involved in immune response skeletal muscle contraction negative regulation of systemic arterial blood pressure chromatin organization inflammatory response immune response JAK-STAT cascade circadian rhythm negative regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage response to xenobiotic stimulus response to mechanical stimulus response to virus response to bacterium response to salt stress response to fructose negative regulation of heart rate vascular endothelial growth factor production positive regulation of gene expression negative regulation of gene expression positive regulation of macrophage derived foam cell differentiation negative regulation of lipid storage response to activity calcium-mediated signaling positive regulation of protein complex assembly positive regulation of defense response positive regulation of fever generation negative regulation of myelination lipopolysaccharide-mediated signaling pathway response to nutrient levels response to lipopolysaccharide negative regulation of interleukin-6 production positive regulation of chemokine production positive regulation of fractalkine production positive regulation of interleukin-1 beta production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production tumor necrosis factor-mediated signaling pathway positive regulation of heterotypic cell-cell adhesion toll-like receptor 3 signaling pathway response to isolation stress response to macrophage colony-stimulating factor regulation of cell proliferation vasodilation positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein complex disassembly positive regulation of MAPK cascade positive regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration negative regulation of viral genome replication innate immune response positive regulation of nitric oxide biosynthetic process response to ethanol regulation of fat cell differentiation negative regulation of fat cell differentiation negative regulation of osteoblast differentiation positive regulation of osteoclast differentiation positive regulation of protein catabolic process positive regulation of action potential positive regulation of cell adhesion positive regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter negative regulation of glucose import positive regulation of JNK cascade response to antibiotic astrocyte activation embryonic digestive tract development positive regulation of smooth muscle cell proliferation regulation of epithelial cell proliferation positive regulation of inflammatory response negative regulation of neurogenesis regulation of developmental process regulation of insulin secretion modulation of synaptic transmission positive regulation of synaptic transmission regulation of synapse organization cognition leukocyte tethering or rolling detection of mechanical stimulus involved in sensory perception of pain negative regulation of lipid catabolic process positive regulation of membrane protein ectodomain proteolysis regulation of secretion positive regulation of protein transport regulation of multicellular organismal process response to glucocorticoid positive regulation of hair follicle development positive regulation of protein kinase B signaling regulation of synaptic transmission, glutamatergic positive regulation of glial cell proliferation positive regulation of vitamin D biosynthetic process negative regulation of vascular wound healing negative regulation of branching involved in lung morphogenesis positive regulation of ERK1 and ERK2 cascade positive regulation of calcineurin-NFAT signaling cascade cellular response to molecule of bacterial origin cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to nicotine cellular response to interferon-gamma cellular response to ionizing radiation positive regulation of mononuclear cell migration positive regulation of podosome assembly endothelial cell apoptotic process protein localization to plasma membrane negative regulation of oxidative phosphorylation inflammatory response to wounding extrinsic apoptotic signaling pathway cellular response to toxic substance liver regeneration necroptotic signaling pathway negative regulation of bile acid secretion antiviral innate immune response response to Gram-negative bacterium positive regulation of neuroinflammatory response positive regulation of interleukin-33 production positive regulation of cytokine production involved in inflammatory response negative regulation of beta-amyloid clearance positive regulation of NIK/NF-kappaB signaling positive regulation of synoviocyte proliferation positive regulation of beta-amyloid formation response to L-glutamate positive regulation of neutrophil activation negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of protein localization to plasma membrane regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly positive regulation of cellular protein localization response to resveratrol cellular response to beta-amyloid positive regulation of vascular smooth muscle cell proliferation response to hydrogen sulfide positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of leukocyte adhesion to arterial endothelial cell response to quercetin response to 3,3',5-triiodo-L-thyronine response to gold nanoparticle positive regulation of protein localization to cell surface positive regulation of blood microparticle formation positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of hepatocyte proliferation regulation of endothelial cell apoptotic process regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process negative regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand