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Mouse splenocytes were unstimulated (top) or stimulated for 5 hours with Cell Stimulation Cocktail (plus protein transport inhibitors) (bottom), then intracellularly stained with Anti-Mouse CD4 eFluor® 450 and 1 ug of Anti-Mouse/Rat TNF alpha PE-Cyanine7 (A18507). Total viable cells, as determined by Fixable Viability Dye eFluor® 780, were used for analysis.
|Tested species reactivity||Mouse|
|Host / Isotype||Armenian hamster / IgG|
|Immunogen||mouse tumor necrosis factor alpha|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
APC1 protein; cachectin; macrophage-derived; member 2; monocyte-derived; TNF; TNF superfamily; TNF-a; TNFA; tumor necrosis factor; tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
DIF; Tnf; TNF-a; TNF-alpha; Tnfa; TNFalpha; Tnfsf1a; TNFSF2