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|Tested species reactivity||Human|
|Published species reactivity||Dog, Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant human TNF-alpha|
|Storage buffer||PBS, pH 7.5|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Production of antibodies to canine IL-1beta and canine TNF to assess the role of proinflammatory cytokines.||Baggio V,Ott F,Fischer RW,Gram H,Peele J,Spreng D,Schmökel H,Jungi TW||Veterinary immunology and immunopathology (107:27)||2005|
|Human||Not Cited||Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6.||Messmann RA,Ullmann CD,Lahusen T,Kalehua A,Wasfy J,Melillo G,Ding I,Headlee D,Figg WD,Sausville EA,Senderowicz AM||Clinical cancer research : an official journal of the American Association for Cancer Research (9:562)||2003|
APC1 protein; Cachectin; macrophage-derived; member 2; monocyte-derived; TNF; TNF superfamily; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; TNF-alpha; TNFA; Tumor necrosis factor; tumor necrosis factor alpha; tumor necrosis factor ligand 1F; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
DIF; TNF; TNF-alpha; TNFA; TNFSF2; TNLG1F