|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Rat / IgG1|
|Immunogen||Mouse TNF Alpha.|
|Storage buffer||PBS with BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-¿ pathway.
RM9011 was used in immunohistochemistry to assess the role of the TNF-alpha pathway after long-term sleep fragmentation in mice
|Ramesh V,Nair D,Zhang SX,Hakim F,Kaushal N,Kayali F,Wang Y,Li RC,Carreras A,Gozal D||Journal of neuroinflammation (9:null)||2012|
Investigation of the role of TNF-¿ converting enzyme (TACE) in the inhibition of cell surface and soluble TNF-¿ production by acute ethanol exposure.
RM9011 was used in flow cytometry to elucidate how ethanol inhibits TLR3 and TLR4 mediated TNF-α secretion.
|von Maltzan K,Tan W,Pruett SB||PloS one (7:null)||2012|
Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion.
RM9011 was used in flow cytometry to discuss PG490-88.
|Chen BJ,Liu C,Cui X,Fidler JM,Chao NJ||Transplantation (70:1442)||2000|
Viral escape by selection of cytotoxic T cell-resistant variants in influenza A virus pneumonia.
RM9011 was used in flow cytometry to study the importance of CD8(+) cytotoxic T lymphocytes during influenza A viral persistence.
|Price GE,Ou R,Jiang H,Huang L,Moskophidis D||The Journal of experimental medicine (191:1853)||2000|