|Functional Assay (FN)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|Host / Isotype||Rat / IgG1, kappa|
|Immunogen||Recombinant mouse TNF-alpha|
|Contains||0.1% sodium azide|
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
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Protein Aliases: APC1 protein; Cachectin; macrophage-derived; member 2; monocyte-derived; TNF; TNF superfamily; TNF-a; TNF-alpha; TNFA; Tumor necrosis factor; tumor necrosis factor alpha; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
Gene Aliases: DIF; Tnf; TNF-a; TNF-alpha; Tnfa; TNFalpha; Tnfsf1a; TNFSF2
UniProt ID: (Mouse) P06804
Entrez Gene ID: (Mouse) 21926
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