Description: BMS1046 (LTX-22) is reportded for ELISA and ICH applications.
Applications Tested: ELISA, Immunohistochemistry (Frozen).
Source: Plant expressed 164 amino acids (Cys32-Thr194) with 16 amino acid Histidine tag. accession NP_002000.
Bioactivity: The ED50 of this protein, as measured by proliferation assay of 4MBr5 monkey epthelial cells, is less than or equal to 4 ng/mL. This corresponds to a specific activity of greater than or equal to 2.5 x 10e5 Units/mg.
Endotoxin: Less than 0.005 ng/ug (0.05 EU/ug) as measured by turbidity assay. Purity: Greater than or equal to 95% as determined by SDS-PAGE.
Molecular Weight: 21.2 kDa but with glycosylation the apparent molecular weights are 26 and 28 kDa.
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DAMA-25N12.13; LT; LT-alpha; Lymphotoxin-alpha; TNF superfamily, member 1; TNF-beta; TNFB; TNFSF1; tumor necrosis factor beta; tumor necrosis factor ligand 1E; Tumor necrosis factor ligand superfamily member 1
Gene Aliases: LT; LTA; TNFB; TNFSF1; TNLG1E
UniProt ID: (Human) P01374
Entrez Gene ID: (Human) 4049