This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.
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Protein Aliases: A20; A20p37; A20p50; OTU domain-containing protein 7C; OTUD7C; Putative DNA-binding protein A20; TNF alpha induced protein 3; TNF alpha-induced protein 3; TNFA1P2; TNFAIP3; Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; Zinc finger protein A20
Gene Aliases: A20; AISBL; OTUD7C; TNFA1P2; TNFAIP3
UniProt ID: (Human) P21580