MA5-15726 targets TNFRSF11B in IHC and WB applications and shows reactivity with Human samples.
The MA5-15726 immunogen is purified recombinant fragment of human TNFRSF11B expressed in E. Coli.
MA5-15726 detects TNFRSF11B which has a predicted molecular weight of approximately 60kDa.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Protein Aliases: MGC29565; Osteoclastogenesis inhibitory factor; Osteoprotegerin; soluble OPG; soluble Osteoprotegerin; sOPG; Tumor necrosis factor receptor superfamily member 11B; tumor necrosis factor receptor superfamily, member 11b
Gene Aliases: OCIF; OPG; PDB5; TNFRSF11B; TR1
UniProt ID: (Human) O00300
Entrez Gene ID: (Human) 4982
Molecular Function: transmembrane signal receptor