Sequence of this protein is as follows: ASNLIGTYRH VDRATGQVLT CDKCPAGTYV SEHCTNTSLR VCSSCPVGTF TRHENGIEKC HDCSQPCPWP MIEKLPCAAL TDRECTCPPG MFQSNATCAP HTVCPVGWGV RKKGTETEDV RCKQCARGTF SDVPSSVMKC KAYTDCLSQN LVVIKPGTKE TDNVCGTLPS FSSSTSPSPG TAIFPRPEHM ETHEVPSSTY VPKGMNSTES NSSASVRPKV LSSIQEGTVP DNTSSARGKE DVNKTLPNLQ VVNHQQGPHH RHILKLLPSM EATGGEKSST PIKGPKRGHP RQNLHKHFDI NEH
DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
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Protein Aliases: CD358; Death receptor 6; Death receptor-6; MGC31965; sCD358; sDR6; soluble CD358; soluble DR6; TNFR-related death receptor 6; Tumor necrosis factor receptor superfamily member 21; tumor necrosis factor receptor superfamily, member 21
Gene Aliases: BM-018; CD358; DR6; TNFRSF21; UNQ437/PRO868
UniProt ID: (Human) O75509
Entrez Gene ID: (Human) 27242