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Product Details
67948-1-IG150UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1E9H3
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
TNIK or TRAF2 and NCK interacting kinase is characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function. TNIK is mainly expression in brain, heart, and spleen and it is a specific effector of RAP2 which regulate actin cytoskeleton. TNIK is autophosphorylated in a manner dependent upon lys54 in the ATP-binding pocket of its kinase domain and plays a main role in cytoskeleton regulation. TNIK has also been shown to phosphorylate gelsolin, the principal intracellular and extracellular actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: TRAF2 and NCK-interacting protein kinase
Gene Aliases: KIAA0551; TNIK
UniProt ID: (Human) Q9UKE5
Entrez Gene ID: (Human) 23043
positive regulation of protein phosphorylation
positive regulation of defense response to virus by host
protein phosphorylation
cytoskeleton organization
activation of JNKK activity
Wnt signaling pathway
microvillus assembly
actin cytoskeleton reorganization
intracellular signal transduction
protein autophosphorylation
regulation of dendrite morphogenesis
protein localization to plasma membrane
xenophagy
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