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Product Details
68158-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F10B3
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MMEAIKKKMQ MLKLDKENAL DRAEQAEAEQ KQAEERSKQL EDELAAMQKK LKGTEDELDK YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL DRAQERLATA LQKLEEAEKA ADESERGMKV IENRALKDEE KMELQEIQLK EAKHIAEEAD RKYEEVARKL VIIEGDLERT EERAELAESK CSELEEELKN VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA EFAERSVAKL EKTIDDLEDE LYAQKLKYKA ISEELDHALN DMTSI
Target Information
TPM3 (tropomyosin 3) is a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-tropomyosin, slow skeletal; cytoskeletal tropomyosin TM30; epididymis luminal protein 189; epididymis secretory sperm binding protein Li 82p; Gamma-tropomyosin; heat-stable cytoskeletal protein 30 kDa; hTM5; skalphaTM.2; TPM3 protein; tropomyosin; tropomyosin 5; Tropomyosin alpha-3 chain; tropomyosin gamma; Tropomyosin-3; Tropomyosin-5
Gene Aliases: CAPM1; CFTD; gamma-TM; HEL-189; HEL-S-82p; hscp30; hTM30nm; hTMnm; NEM1; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TM5; Tm5NM; TMnm; Tpm-5; TPM3; Tpm5; TPMsk3; TRK; Trop-5
UniProt ID: (Human) P06753, (Mouse) P21107
Entrez Gene ID: (Human) 7170, (Pig) 414388, (Mouse) 59069
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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