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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant, full length human protein.|
|Storage buffer||tissue culture supernatant diluted in PBS, pH 7.6, with 15mg/ml BSA|
|Contains||0.05% sodium azide, 0.01% thimerosal|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|ELISA (ELISA)||0.5-1 µg/ml|
|Inhibition Assays (IA)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-24733 detects TRAIL from human samples.
MA1-24733 has been successfully used in ELISA, IA, neutralization and Western blot procedures. Monoclonal anti-TRAIL neutralizes bioactivity on mouse L929 cells. The ND50 is approximately 2-8 ng/ml in the presence of 12 ng/ml of cross-linked recombinant human TRAIL, using mouse L929 cells.
The MA1-24733 immunogen is recombinant, full length human protein.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Apo-2 Ligand; Apo2L; CD253 antigen; chemokine tumor necrosis factor ligand superfamily member 10; superfamily member 10; TNF-related apoptosis inducing ligand TRAIL; TNF-Related Apoptosis-Inducing Ligand; TNFSF10; TRAIL protein; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; Tumor necrosis factor ligand; tumor necrosis factor ligand 6A
Apo-2L; APO2L; CD253; TL2; TNFSF10; TNLG6A; TRAIL