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Staining of non-transfected (top) and mouse DR5 transfected (bottom) BHK cells with 0.125 µg of Golden Syrian Hamster IgG Isotype Control PE (open histogram) or 0.125 µg of Anti-Mouse CD262 (DR5) PE (filled histogram, A18414). Total viable cells were used for analysis.
|Tested species reactivity||Mouse|
|Host / Isotype||Hamster / IgG|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kappa-B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Ly98, DR5, MK, TRICKB, TRICK2B, KILLER, TRICK2A, TRAILR2
KILLER/DR5 TRAIL death-inducing receptor, death receptor 5, tumor necrosis factor receptor superfamily member 10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9, Trail receptor 2