|Tested species reactivity||Human, Mouse|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide corresponding to residues E V P Q Q T V A P Q Q Q R H S F K G E E C P A G S H R S E H T C of human TRAIL Receptor 3.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2, with 0.14M NaCl, 1mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||-80° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:900-1:1100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-26368 detects TRAIL Receptor 3 from human samples.
PA1-26368 has been successfully used in Western blot, ELISA, and IF procedures.
The PA1-26368 immunogen is a synthetic peptide corresponding to residues E V P Q Q T V A P Q Q Q R H S F K G E E C P A G S H R S E H T C of human TRAIL Receptor 3.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.