|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 171 and 368 of Human TRAIP|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
PA5-27699 targets TRAIP in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-27699 immunogen is recombinant fragment corresponding to a region within amino acids 171 and 368 of Human TRAIP.
This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage.
PA5-27699 was used in immunohistochemistry to report that the RAP80-binding partner TRAIP regulates recruitment of the damage signaling machinery and promotes homologous recombination
|Soo Lee N,Jin Chung H,Kim HJ,Yun Lee S,Ji JH,Seo Y,Hun Han S,Choi M,Yun M,Lee SG,Myung K,Kim Y,Chul Kang H,Kim H||Nature communications (7:null)||2016|