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Invitrogen
TREX1 Recombinant Rabbit Monoclonal Antibody (PSH08-84)
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FIGURE: 1 / 3
TREX1 Antibody (MA570060) in WB
Western blot analysis of TREX1 in various lysates. Samples were incubated with TREX1 monoclonal antibody (Product # MA570060) using a dilution of 1:5,000 in 5% NFDM/TBST at 4°C overnight followed by Goat Anti-Rabbit IgG - HRP Secondary Antibody at a dilution of 1:50,000 for 1 hour at room temperature. Lane 1: RAW264.7 cell lysate; Lane 2: CTLL-2 cell lysate; Lane 3: J774A.1 cell lysate; Lane 4: Neuro-2a cell lysate (negative). Lysates/proteins at 20 µg/Lane. Predicted band size: 34 kDa; Observed band size: 35 kDa. Exposure time: Lane 1: 25... View More
Product Details
MA570060
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PSH08-84
Immunogen
Recombinant protein within mouse TREX1 aa 1-280.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: RAW264.7 cell lysate, CTLL-2 cell lysate, J774A.1 cell lysate.
Subcellular location: Nucleus, Cytoplasm, cytosol, Endoplasmic reticulum membrane.
Target Information
Trex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3'-5' exonuclease TREX1; DNase III; three prime exonuclease 1; Three-prime repair exonuclease 1; trophoblast expressed 1
Gene Aliases: 1661; AU041952; Trex1
UniProt ID: (Mouse) Q91XB0
Entrez Gene ID: (Mouse) 22040
nucleic acid binding
double-stranded DNA binding
single-stranded DNA binding
nuclease activity
exonuclease activity
protein binding
3'-5'-exodeoxyribonuclease activity
3'-5' exonuclease activity
exodeoxyribonuclease III activity
hydrolase activity
MutLalpha complex binding
MutSalpha complex binding
adenyl deoxyribonucleotide binding
protein homodimerization activity
metal ion binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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