The TRF2 antibody is referred to as both clone 4A794.15 and 4A794 in the published literature.
This antibody recognizes full-length TRF2 as well as TRF2 forms lacking both the N-terminal basic domain (B) and the telobox Myb-like C-terminal DNA-binding domain (M).
TRF2 forms missing the B and M domains are often referred to as mutant TRF2.Although the exact epitope recognized by the TRF2 antibody has not been mapped, the scientific literature indicates it is in the D or L domain, but not in the B or M domain.
Suggested positive control: HL-60, antigen standard for TERF2 (transient overexpression lysate).
TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length (1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes (1). TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini (2). The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells (2). Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types (3).
1. Broccoli, D., et al. Nature Genetics 17:231-239 (1997).
2. Van Steensel B., et al. Cell 92:401-413 (1998).
3. Karlseder, J., et al. Science 283: 1321-1325 (1999).
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Protein Aliases: Telomeric DNA-binding protein; telomeric repeat binding protein 2; Telomeric repeat-binding factor 2; TRBF2; TRF2; TTAGGG repeat-binding factor 2
Gene Aliases: TERF2; TRBF2; TRF2
Molecular Function: nucleic acid binding