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TRIM24 Antibody (MA5-44756) in IHC (P)
Immunohistochemistry analysis of TRIM24 in paraffin-embedded human bladder carcinoma tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 2 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with TRIM24 Monoclonal antibody (Product # MA5-44756) using a dilution of 1:2,000 for ... View More
Product Details
MA5-44756
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE64-31
Immunogen
Synthetic peptide within human TRIM24 aa 405-455/1,050.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2931214
Target Information
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; RING-type E3 ubiquitin transferase TIF1-alpha; TIF1-alpha; Transcription intermediary factor 1-alpha; transcriptional intermediary factor 1; tripartite motif-containing 24; Tripartite motif-containing protein 24
Gene Aliases: hTIF1; PTC6; RNF82; TF1A; TIF1; TIF1A; TIF1ALPHA; TRIM24
UniProt ID: (Human) O15164
Entrez Gene ID: (Human) 8805
p53 binding
chromatin binding
transcription coactivator activity
protein tyrosine kinase activity
ubiquitin-protein transferase activity
receptor binding
protein binding
zinc ion binding
ligase activity
ligand-dependent nuclear receptor binding
estrogen response element binding
methylated histone binding
sequence-specific DNA binding
ubiquitin protein ligase activity
lysine-acetylated histone binding
chromatin/chromatin-binding, or -regulatory protein
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
protein ubiquitination
peptidyl-tyrosine phosphorylation
protein catabolic process
regulation of protein stability
regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
protein autophosphorylation
calcium ion homeostasis
regulation of vitamin D receptor signaling pathway
cellular response to estrogen stimulus
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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