TRIM27, also designated Ret finger protein (RFP), is a member of the tripartite motif family, which is characterized by a conserved RING finger, a B-box and a coiled-coil domain (together designated RBCC). TRIM27 becomes oncogenic when its RBCC is fused with the tyrosine kinase domain of the RET protein.Normally, TRIM27 functions as a transcriptional repressor and associates with enhancer of polycomb (EPC1) and Mi-2beta, a main component of the nucleosome remodeling and deacetylase (NuRD) complex. TRIM27 is expressedat specific stages of spermatogenesis and in various tissues and can be localized to either the cytoplasm or nucleus depending on the cell type.
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Protein Aliases: Ret finger protein; RFP transforming protein; RING finger protein 76; RING-type E3 ubiquitin transferase TRIM27; RNF76; tripartite motif protein TRIM27; tripartite motif-containing 27; Tripartite motif-containing protein 27; Zinc finger protein RFP
Gene Aliases: RFP; RNF76; TRIM27
UniProt ID: (Human) Q6NXR9
Entrez Gene ID: (Human) 5987