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TRIM8 Antibody (MA5-56723) in WB
Western Blot analysis of TRIM8 using TRIM8 Recombinant Monoclonal Antibody (Product # MA5-56723). PG-4 whole cell extract (30 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with TRIM8 antibody diluted at 1:1,000. A HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody, and the signal was developed with Trident femto Western HRP Substrate.
Product Details
MA5-56723
Product Specifications
Species Reactivity
Cat,
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL2797
Immunogen
Recombinant fragment of human GERP.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
Target Information
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase TRIM8; glioblastoma expressed ring finger protein; Glioblastoma-expressed RING finger protein; probable E3 ubiquitin-protein ligase TRIM8; RING finger protein 27; RING-type E3 ubiquitin transferase TRIM8; tripartite motif protein 8; tripartite motif protein TRIM8; tripartite motif-containing 8; Tripartite motif-containing protein 8
Gene Aliases: GERP; RNF27; TRIM8
UniProt ID: (Human) Q9BZR9
Entrez Gene ID: (Human) 81603, (Rat) 688785
stem cell population maintenance
negative regulation of viral transcription
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
negative regulation of viral entry into host cell
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein localization to nucleus
negative regulation of viral release from host cell
positive regulation of autophagy
protein ubiquitination
interferon-gamma-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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